What is Current Research for Motor Neuron Disease?

Motor neuron disease is a condition that arises when specialized nerve cells (motor neurons) in both the spinal cord and brain stop functioning properly. In the United States, less than 20,000 cases are reported every year, while in the United Kingdom, 3 out of 100,000 individuals are diagnosed with it every year. This condition is chronic and has no cure. Newer treatments are being discovered, which can help people alleviate several symptoms.

Clinical Trials

The MND Association has stated that a lot of clinical trials have led to disappointing results, but even so, they have helped to pave the way for future trails. Researchers are making progress every day.

Innovative Research

research

Several researchers are conducting clinical trials in different parts of the globe to find more solutions to either alleviate this disease or combat it once and for all. Defective genes that could intervene in the development of motor neuron disease are currently being investigated. Researchers believe that stem cells are the master cells of the body and thus have the capability to divide and become any cell. What this means is that they might be utilized to create new motor neurons shortly.

MND Association’s DNA Bank Samples

At the moment, MND Association’s DNA Bank samples are being utilized to obtain more information on the genetic causes of motor neuron disease. In 2014, researchers received access to white blood cells to model this health matter. To this day, more than 3,000 individuals have contributed to the MND Associations DNA Bank in the United Kingdom, and it appears that this number keeps growing. Samples are being used to learn the way variations in the DNA may contribute to the development of motor neuron disease.

Research for Treatment

Even though there is no cure for MND, medications have been formulated to slow the progression of the disease by controlling the symptoms. One of the most common drugs that are prescribed by doctors is Riluzole.

GM604, which is developed by the American pharmaceutical company Genervon, has been used in clinical trials. Twelve people in total utilized it for over a 12-week period and obtained great results from doing so. In February of 2015, the results of this trial were presented to the Food and Drug Administration (FDA), which licenses drugs in the United States. To date, no decision has been made.

In 2013, the drug Nuedexta became available in the United Kingdom, to treat emotional depression associated with MND, as well as other neurological conditions. Unfortunately, in 2016, its marketing authorization was withdrawal from the EU by the request of Avanir Pharmaceutical Inc., who was the developer and of the drug.

Evolvement of Tests

test

Over the years, there have been some tests that make the diagnosis of motor neuron disease easier and faster, including:
transcranial magnetic stimulation,
electromyography,
magnetic resonance imaging study, and nerve tests.

The transcranial magnetic stimulation measures the activity of nerves that travel from the brain to one’s spinal cord. Electromyography consists of thin needles to measure the electrical activity of muscles. On the other hand, nerve tests consist of an electrical impulse that is applied via a small pad that is placed on the skin. The magnetic resonance imaging study utilizes radio waves and magnets to produce images of the inside of one’s body.

Research Continues

Studies continue on motor neuron disease by the MND Association, pharmaceutical companies, and other establishments. Only time will tell how far the medical field progresses in solving this health issue.

How Does Diet Affect Motor Neuron Disease?

 

good food

Motor neurons are important nerve cells that are responsible for voluntary muscle control. A motor neuron disease is a neurological disorder that severely impacts these cells. These severe conditions include ALS (amyotrophic lateral sclerosis, PLS (primary lateral sclerosis) and PMA (progressive muscular atrophy). Living with these diseases can be a physical and emotional struggle for the patient as well as those caring for them.

A diagnosis of MND can be devastating because there is no known cure. Recent studies have found that there is a link between diet and motor neuron diseases. Certain foods can make it easier to keep up nutrition levels and health and potentially slow down disease progression.

The Importance Of Food

Maintaining a healthy diet is necessary because without proper nutrition other health problems can occur. Extended muscular atrophy, as well as weakened immune systems, will contribute to the risk of infection or development of other diseases. Energy deficiency can cost a great deal to those suffering from motor neuron diseases. Without energy the body will shut down, making it defenseless thus decreasing longevity.

glucose

Limiting sugar is necessary for the MND patient. It is imperative to find a way to detox the body. Finding a good detox plan can be extremely helpful.

 

 

 

Nutrition and Motor Neuron Diseases

 

Eating and swallowing are impacted by the weakening of muscles caused by these conditions, so keeping up nutrition levels can be a challenge. Some changes can be made to the diet to help relieve this. Foods should be eaten in small portions frequently. It is also important to ensure texture is soft and easy to swallow. Fluid intake is essential to ensure the patient keeps hydrated, thus preventing discomfort. Often a liquid diet is beneficial in more advanced cases, so the patient can get what they need without the physical pains of eating.

New Research

A recent study funded by the Muscular Dystrophy Association found a connection between high-calorie foods and increased life expectancy. Using a high-fat formula, patients increased weight and appeared to live longer and showed a slower progression of the disease. The diet can be provided using tube feeding if the disease has already interfered with swallowing muscles.

While there is no cure for these diseases, it becomes necessary to take steps to slow the progression of the disease. Diet is a way to help the patient.

How the Car Racing Community Supports the MND Foundation

About MND

The Motor Neurons Disease (MND) is arguably one of the deadliest diseases and also responsible for a significant percentage of deaths in the world. This neurological condition attacks the nerves in the brain and spinal cord. Walking, eating and talking are affected by the disease eventually causing complete paralysis.

There is no cure for MND, and the onset of the disease leads people to require wheelchairs and eventually round the clock healthcare. The disease costs the patient a significant amount of money. However, only a handful of patients can afford the proper care to manage the disease.

Aussie Racing’s Relationship with the MND Foundation

Currently, the car racing community leads the efforts of supporting patients through MND donations. One of the most popular organizations that support MND is Aussie Racing Cars.

Aussie Racing Cars is a popular racing category where cars are built over motorcycle chassis.  The vehicles are called silhouette cars and raced by men and  women.

Jeff Watters, a driver from Melbourne, had a close friend who lost his life to MND. After seeing first hand how devastating the disease is, Jeff has dedicated his life to supporting MND victims and raising awareness about this disease. Jeff began his initiative in 2013 and with time has made MND awareness a huge part of Aussie racing.

Aussie Racing Cars makes MND their official charity. Through their support, families, and victims get to enjoy a firsthand experience of the track and behind the scenes of Aussie racing. This MND charity initiative has attracted several sponsors which include: Hertz Australia, Peddlers Suspension, Aughtersones Insurance Brokers among others.

Aussie 96 Car
Jeff Watters #96 MND Car, from google images

There is even a branded MND car. Number 96 Autosport Racing car was renamed the number 96 Cure for MND Racing Car. Jeff Waters drives this car and also provides it for fan pictures. The car provides a reminder of how important the MND foundation is.

The Aussie Racing MND campaign has given many patients access to expensive specialized treatment. Aussie racing is hugely popular thus making it the leading MND charity organization in the world.

MND Charity Virtual Races

Aussie Racing boosts its efforts to raise money by introducing fans to virtual races. These virtual races provide an opportunity for donators to show their support towards MND. The virtual race involves running or walking on a treadmill at a racetrack.

At the end of the event, a participant receives a sticker that shows support for the fight against MND. These virtual races are not only fun but also allow supporters of the movement and victims alike to come together, interact and comfort each other.

Conclusion

MND is a devastating disease that has no cure. For that reason, it is important that money is channeled to research to find a cure. And while we wait for that cure, money also has to go to patients to help them be as comfortable as possible.

Hats off to Aussie Racing for their help in raising money for MND.

What is Motor Neuron Disease?

 

Human beings face a lot of challenges during their lifetime. The most difficult come as critical health conditions. Some illnesses may arise from genetic modifications, or from the surrounding environment. Motor Neuron Disease is the term for a group of diseases where neuron messages stop going to muscles. There is no cure for MND, and it is unclear what the cause is.

What is MND?

neuron connectors

MND is a progressive neurological condition which affects the motion neurons in the brain and the spinal cord. The illness makes communication between the brain, spinal cord, and other muscles difficult and eventually leads to the atrophy and wasting of the muscles. As the disease progresses, speech is impaired, walking, holding items, eating, and even breathing becomes difficult.

Common Symptoms of Motor Neuron Disease

The symptoms of MND do not happen all at once; they may also differ from one person to another. The symptoms can include:

  • Muscle cramps and spasms in the hands and feet. Changing positions or light exercise can be therapeutic. However, in severe cases, the doctor may prescribe a muscle relaxant
  • Stiffness of joints, which can also be helped by gentle exercises
  • Difficulty in communicating, often characterized by slurred speech
  • Problems swallowing food and water
  • Breathing problems due to weakening of the respiratory muscles
  • Choking or coughing, often associated with difficulty in swallowing as the saliva blocks the airways

Types of Motor Neuron Disease

There are four main types of MND. They affect people differently. Although the condition is not very common, it’s fatal when it occurs. It’s uncommon to get two types of the conditions, although the symptoms may overlap making it hard to distinguish one from another.

Amyotrophic lateral sclerosis (ALS)

ALS is the most common type of MND that affects a lot of people. It affects both the top and the lower motor neurons. Weariness and the wastage of limbs are characteristics of ALS. Weakness makes it difficult to hold items and also leads to tripping while walking. Upon onset of the symptoms, the Life expectancy is two to five years on average.

Progressive Muscular Atrophy (PMA)

PMA is rarer than the other MND’s. It’s also less severe and affects mainly the lower body neurons. Upon onset of the symptoms, one may live for over five years. Early symptoms include clumsiness of the hands.

Progressive Bulbar Palsy (PBP)

Out of the people diagnosed with MND, about a quarter of them suffer from PBP. It affects both the upper and the bottom motion neurons. Slurred speech is among the first symptoms. Life expectancy is however small, with those affected living an average of six months to three years of onset of the symptoms.

Treatment of MND

pills

There is no known cure for the disease. However, treatment may help lengthen lifespan while at the same time making the condition much easier to deal with. The only approved drug is Rizole. It does help extend life but is not a cure. Making plans for care is essential for the MND patient.